Author

Timo Oosenbrug

Leiden University Medical CenterORCID 0000-0002-7533-0595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Annemarthe G. Van der VeeniD· 3 shared Adán Pinto-FernándeziD· 2 shared Benedikt Mathias KessleriD· 2 shared Dennis GravekampiD· 2 shared Laurens R. ter HaariD· 2 shared Andreas WackiD· 1 shared Annick R KooijiD· 1 shared Ayşegül SapmaziD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

Annemarthe G. Van der VeenORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A noncanonical function of Dicer fuels self-dsRNA-driven inflammation

Laurens R. ter Haar, Sabine de Lange, Dennis Gravekamp, Annick R Kooij, Jasper W. de Wolf, Yanniek Asschert, Timo Oosenbrug, Maarten W. Paul, Peter A. van Veelen, Willeke M.C. van Roon-Mom, Hailiang Mei, Annemarthe G. Van der Veen

This study identifies a noncanonical role for Dicer in regulating self-dsRNA sensing and innate immune responses to self-derived double-stranded RNA.

bioRxiv · Nov 3, 2026 · PreprintImmunology

USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10

Rishov Mukhopadhyay, Simeon D. Draganov, Timo Oosenbrug, Jimmy J. L. L. Akkermans, Marjolein Kikkert, Klaus‐Peter Knobeloch, Günter Fritz, M Ángeles Guzmán, Sonia Zúñiga, Robbert. Q. Kim, Annemarthe G. van der Veen, Benedikt Mathias Kessler, Adán Pinto-Fernández, Paul P. Geurink, Ayşegül Sapmaz

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

Nature Communications · Jun 19, 2026Peer-reviewedBiochemistry

The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors

Timo Oosenbrug, Dennis Gravekamp, Adán Pinto-Fernández, Stefania Crotta, Katja Finsterbusch, Sander B. van der Kooij, Laurens R. ter Haar, Yanniek Asschert, Gilaine F.E. Kleian, Benedikt Mathias Kessler, Andreas Wack, Annemarthe G. van der Veen

This study shows Huwe1 is essential for RIG-I-like receptor-mediated type I and III IFN induction by ubiquitinating key pathway components like TRAF5.

bioRxiv · Mar 27, 2025 · PreprintImmunology