Author

Laurens R. ter Haar

Leiden University Medical CenterORCID 0000-0002-9237-0142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Annemarthe G. Van der VeeniD· 3 shared Dennis GravekampiD· 3 shared Peter A. van VeeleniD· 2 shared Sander B. van der KooijiD· 2 shared Timo OosenbrugiD· 2 shared Adán Pinto-FernándeziD· 1 shared Andreas WackiD· 1 shared Annick R KooijiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

Annemarthe G. Van der VeenORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A noncanonical function of Dicer fuels self-dsRNA-driven inflammation

Laurens R. ter Haar, Sabine de Lange, Dennis Gravekamp, Annick R Kooij, Jasper W. de Wolf, Yanniek Asschert, Timo Oosenbrug, Maarten W. Paul, Peter A. van Veelen, Willeke M.C. van Roon-Mom, Hailiang Mei, Annemarthe G. Van der Veen

This study identifies a noncanonical role for Dicer in regulating self-dsRNA sensing and innate immune responses to self-derived double-stranded RNA.

bioRxiv · Nov 3, 2026 · PreprintImmunology

The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors

Timo Oosenbrug, Dennis Gravekamp, Adán Pinto-Fernández, Stefania Crotta, Katja Finsterbusch, Sander B. van der Kooij, Laurens R. ter Haar, Yanniek Asschert, Gilaine F.E. Kleian, Benedikt Mathias Kessler, Andreas Wack, Annemarthe G. van der Veen

This study shows Huwe1 is essential for RIG-I-like receptor-mediated type I and III IFN induction by ubiquitinating key pathway components like TRAF5.

bioRxiv · Mar 27, 2025 · PreprintImmunology

Vault RNAs aid viral infection by facilitating nuclear export of hnRNP C and ELAVL1

Jorn E. Stok, Sander B. van der Kooij, Dennis Gravekamp, Laurens R. ter Haar, Jasper W. de Wolf, Clarisse Salgado‐Benvindo, Tessa Nelemans, Bart J.M. Grijmans, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert, Annemarthe G. van der Veen

This study shows that vault RNAs enhance viral replication by facilitating the nuclear export of ELAVL1 and hnRNP C, which are required for efficient viral replication.

bioRxiv · Oct 7, 2024 · PreprintMolecular Biology