Platelet-Mediated Suppression of T Cell Function Drives Immune Evasion in Triple Negative Breast Cancer through the P-Selectin / PSGL-1 Pathway
Margaret R. Smith-Oliver, Deepa Gautam, Emily M. Clarke, Grace C. Petrarca, Megan E. Sullivan, Giovanni Goggi, Miloš R. Spasić, Natalie Kane, Harvey G. Roweth, Ana Christina Garrido-Castro, Patricia Ellen Davenport, Joanna Bagińska, Sandra S. McAllister, Elisabeth M. Battinelli
This paper identifies a platelet-mediated immune evasion mechanism in TNBC via the P-selectin/PSGL-1 pathway, showing that blocking P-selectin can restore T-cell function and improve ICI response.
bioRxiv · Sep 12, 2025 · PreprintCancer Biology