Stefania Girotto

Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination

This study investigates the RAD51-BRC repeats interaction using computational and experimental methods to better understand its role in homologous recombination and its implications for cancer.

METTL9 sustains vertebrate neural development primarily via non-catalytic functions

The paper investigates METTL9's role in vertebrate neural development, finding its non-catalytic functions sustain neurogenesis through secretory pathway modulation.

Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction

This study combines computational and experimental methods to characterize the conformational dynamics of the RAD51-BRC4 complex, revealing key residues involved in their interaction.

Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.