Jakob Rupert

This study shows RNA binding alters the structure, function, and stability of alpha-synuclein fibrils, suggesting RNA as an active co-factor in amyloid formation.

This study uses RNA aptamers to detect pathological FUS in ALS, showing improved specificity and sensitivity compared to antibodies.

This study investigates how RNA affects alpha-synuclein phase separation, showing RNA induces morphological changes and promotes liquid-to-solid transition.

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.

This paper demonstrates that TDP-43 paralogs in the killifish N. furzeri form amyloid-like aggregates during ageing, suggesting the fish as a model for TDP-43-related neurodegenerative diseases.

The paper analyzes the structural elements of the SARS-CoV-2 genome and predicts human protein interactions, identifying conserved regions and potential host factors involved in viral replication.