Andrea Cavalli

Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination

This study investigates the RAD51-BRC repeats interaction using computational and experimental methods to better understand its role in homologous recombination and its implications for cancer.

Critical Assessment of a Structure-Based Pipeline for Targeting the Long Non-Coding RNA MALAT1

The paper evaluates a structure-based drug discovery pipeline for targeting MALAT1 using 21 ligands, identifying a binding mode that aligns with experimental affinity trends.

Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction

This study combines computational and experimental methods to characterize the conformational dynamics of the RAD51-BRC4 complex, revealing key residues involved in their interaction.

GeNePi: a GPU-enhanced Next Generation Bioinformatics Pipeline for Whole Genome Sequencing Analysis

GeNePi is a GPU-enhanced bioinformatics pipeline for WGS analysis that efficiently identifies genomic variants with performance comparable to state-of-the-art tools.

Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.

Hybridization load introduced by Alpine ibex hybrid swarms

The paper estimates hybridization load in Alpine ibex due to hybridization with domestic goats, finding increased loss-of-function mutations in hybrids compared to non-hybrids.

IsoBayes: a Bayesian approach for single-isoform proteomics inference

IsoBayes infers protein isoform presence and abundance using Bayesian methods integrating proteomics and transcriptomics data, showing good sensitivity and specificity in simulations and real datasets.

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

The paper captures the release of a photopharmacological drug from tubulin using time-resolved serial crystallography and shows how ligand release triggers conformational changes.

Probing interplays between human XBP1u translational arrest peptide and 80S ribosome

This study uses molecular dynamics simulations to investigate XBP1u AP-ribosome interactions and their variants, revealing insights into the mechanism of translational arrest.