Glyn Bradley

An atlas of protein-protein associations of human tissues prioritizes candidate disease genes

The paper constructs a tissue-specific protein interaction atlas using proteomic data from 11 human tissues, identifying key drivers of inter-tissue variation and prioritizing disease genes in brain disorders.

Network expansion of genetic associations defines a pleiotropy map of human cell biology

The paper uses network-based expansion of GWAS results to identify pleiotropic gene modules linked to multiple traits and demonstrates their application in studying inflammatory bowel disease.

Simple Causal Relationships in Gene Expression Discovered through Deep Learned Collective Variables

The paper develops a deep learning approach to identify simple causal relationships in gene expression by finding low-dimensional representations that predict genetic perturbation responses.

CausalTab: PSI-MITAB 2.8 updated format for signaling data representation and dissemination

The paper introduces CausalTAB, an updated format for representing causal signaling interactions, enhancing the precision and coverage of signaling network modeling.