The paper uses network-based expansion of GWAS results to identify pleiotropic gene modules linked to multiple traits and demonstrates their application in studying inflammatory bowel disease.

Nature Genetics · Feb 23, 2023Peer-reviewedGenetics

The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions

Livia Perfetto, Chiara Pastrello, Noemí del‐Toro, Margaret Duesbury, Marta Iannuccelli, Max Kotlyar, Luana Licata, Birgit Meldal, Kalpana Panneerselvam, Simona Panni, Negin Rahimzadeh, Sylvie Ricard‐Blum, Łukasz Salwiński, Anjali Shrivastava, Gianni Cesareni, , Pablo Porras

The paper curates a dataset of physical molecular interactions between SARS-CoV-2, SARS-CoV-1, and other Coronaviridae proteins, providing a resource for studying virus-host interactions.

Database · Jan 1, 2020Peer-reviewedBioinformatics

Capturing variation impact on molecular interactions: the IMEx Consortium mutations data set

J. Khadake, Birgit Meldal, Simona Panni, David Thorneycroft, K. Van Roey, Sara Abbani, Łukasz Salwiński, Matteo A. Pellegrini, Marta Iannuccelli, Luana Licata, G. Cesareni, Bernd Roechert, Alan James Bridge, Mais G. Ammari, Fiona McCarthy, , Pablo Porras

The paper presents a dataset of 28,000 annotations describing how amino acid mutations affect protein interactions, available through the IntAct website.

Nature Communications · Dec 27, 2018Peer-reviewedBioinformatics