Author

Gonzalo Laje

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Research Focus:polygenic risk· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Abesh Kumar Bhattacharjee· 2 shared Alessio SquassinaiD· 2 shared Alexandre G. DayeriD· 2 shared Alfonso Antonio Vincenzo TortorellaiD· 2 shared Andrea Hofmann· 2 shared Andrea PfennigiD· 2 shared Andreas J. ForstneriD· 2 shared Andreas ReifiD· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Abesh Kumar Bhattacharjee

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders

Janet L. Cunningham, Jennifer Frankovich, Robert A. Dubin, Erika Pedrosa, Refıa Nur Baykara, Noelle Schlenk, Shahina Bano Maqbool, Hedwig Dolstra, Jacqueline Marino, Jacob Edinger, Julia M. Shea, Gonzalo Laje, Sigrid M. A. Swagemakers, Siamala Sinnadurai, Zhengdong D. Zhang, , Herbert M. Lachman

The paper reports mutations in DNA damage repair genes in patients with acute psychiatric symptoms or regression, suggesting a link between DNA repair defects and inflammatory brain conditions.

Developmental Neuroscience · Oct 11, 2024Peer-reviewedGenetic & Genomic Medicine

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott Richard Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola Ayele, Yi‐Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, , Mario Maj

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

bioRxiv · Oct 26, 2018 · PreprintGenomics

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott Richard Clark, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola Ayele, Yi‐Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, , Gustavo Turecki

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.

bioRxiv · Nov 11, 2017 · PreprintGenetics