Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor
Spiros Palikyras, Konstantinos Sofiadis, Athanasia Stavropoulou, Adi Danieli‐Mackay, Vassiliki Varamogianni‐Mamatsi, David Hörl, Simona Nasiscionyte, Yajie Zhu, Ioanna Papadionysiou, Antonios Papadakis, Nataša Josipović, Anne Zirkel, Aoife O’Connell, Gary Loughran, James Keane, , Argyris Papantonis
This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.
Aging Cell · Jan 9, 2024Peer-reviewedGenomics