Cortactin regulates metastatic dormancy of circulating tumor cells by suppressing mTOR-dependent senescence
Jianyang Hu, Binyu Zhang, Junhao Chen, Guanyin Huang, Hongchao Zhou, Fan Yang, Ke Liu, Shuqian Zheng, Xuefei Liu, Jia-Ling Liu, Hailiang Hu, Lvhua Wang, Jianglin Zhang, Lingyun Dai, Qingfeng Chen, , Xin Hong
This study identifies cortactin's role in suppressing mTOR-dependent senescence in CTCs, leading to metastatic dormancy, and proposes a therapeutic strategy combining cortactin depletion and senolytics.
bioRxiv · Mar 26, 2025 · PreprintCancer Biology