Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice
Guo Xueshui, Ravindra Singh Prajapati, Jiyeon Chun, Insuk Byun, Kamil K. Gebis, Yizhi Wang, Karen Ling, Casey Dalton, Jeff A. Blair, Anahid Hamidianjahromi, Gemma Bachmann, Frank Rigo, Paymaan Jafar‐Nejad, Jeffrey N. Savas, Min Jae Lee, , Robert Gordon Kalb
This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.
bioRxiv · Sep 10, 2024 · PreprintNeuroscience