Mast cell-driven adipocyte lipolysis promotes post-expansive VAT atrophy and ectopic hepatic steatosis
Jiahui Wang, Lei Zhang, Wen‐Yue Liu, Xin-Zhe Jin, Hao Yin, Hao Cai, Hai‐Yang Yuan, WAH YANG, Bin Bao, Ming‐Hua Zheng, Hua Wang, Guo-Ping Shi, Xian Zhang, Jian Liu
This study identifies mast cells and their derived serotonin as drivers of adipocyte lipolysis, leading to visceral fat atrophy and hepatic steatosis in obesity.
bioRxiv · Jan 8, 2026 · PreprintCell Biology