Jian Liu

LineageFlow: Growth-Corrected State Dynamics for Probabilistic Cell-Fate Prediction

LineageFlow predicts clonal fate and transcriptional profiles by integrating growth dynamics and state transitions in single-cell lineage data.

Cell line resources for the study of neurofibromin: functions, phenotypes, and drug discovery/development

The paper presents and characterizes human cell lines with NF1 gene variants for studying neurofibromin function, phenotypes, and drug development.

Inflammatory arthritis disrupts ocular immune privilege by compromising blood-retinal barrier integrity and promoting uveitogenic T cell recruitment

This study shows inflammatory arthritis disrupts the blood-retinal barrier and promotes T cell recruitment to the eye, increasing susceptibility to uveitis without causing overt ocular disease.

SEMFA: A General Framework for Inferring Statistical Significance of Mahalanobis Similarity between Multi-Omics Profiled Samples Built on Multiple Factor Analysis

SEMFA infers the statistical significance of Mahalanobis similarity between multi-omics samples using multiple factor analysis, showing effectiveness in both Gaussian and non-Gaussian scenarios.

Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas

The paper develops and characterizes semi-immortalized Schwann cell lines from NF1-associated cutaneous neurofibromas to aid in studying and developing therapies for NF1.

Mast cell-driven adipocyte lipolysis promotes post-expansive VAT atrophy and ectopic hepatic steatosis

This study identifies mast cells and their derived serotonin as drivers of adipocyte lipolysis, leading to visceral fat atrophy and hepatic steatosis in obesity.

Comprehensive profiling of antibiotic resistance, virulence genes, and mobile genetic elements in the gut microbiome of Tibetan antelopes

This study profiles antibiotic resistance, virulence genes, and mobile genetic elements in Tibetan antelope gut microbiomes, identifying species-specific resistance and potential human pathogen strains.

Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21

This study identifies small-molecule ligands for TRIM21, an E3 ligase, demonstrating their ability to degrade nuclear pore complex proteins and induce cell death in cancer cells.

TSTA: Thread and SIMD-Based Trapezoidal Pairwise/Multiple Sequence Alignment Method

The paper introduces TSTA, a parallel sequence alignment method that improves efficiency using thread and SIMD parallelism for pairwise and multiple sequence alignments.

Synthetic control of actin polymerization and symmetry breaking in activeprotocells

The paper demonstrates symmetry breaking in an active protocellular system through externally-controlled actin polymerization in giant unilamellar vesicles.

Genetically Encoded FRET Biosensor for Live-cell Visualization of Lamin A Phosphorylation at Serine 22

This paper develops a FRET-based biosensor to visualize lamin A phosphorylation at Serine 22 in live cells, revealing its dynamics during the cell cycle and its role in nuclear envelope breakdown.

CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

The paper introduces a new sequencing chemistry (CoolMPS) that improves signal intensity and eliminates scar interference in massively parallel sequencing.

Protein Gradients on the Nucleoid Position the Carbon-fixing Organelles of Cyanobacteria

The paper identifies McdB as a protein that interacts with McdA to create oscillatory patterns on the nucleoid, enabling equidistant positioning of carboxysomes in cyanobacteria.