Identification and Validation of an inhibitor of the protein kinases PIM and DYRK
Gyula Bencze, Prabhadevi Venkataramani, Elad Elkayam, Keith D. Rivera, Ankur Garg, Istvan Szabadakai, László Őrfi, Leemor Joshua‐Tor, Darryl Pappin, Nicholas K. Tonks
This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.
Journal of Medicinal Chemistry · Mar 18, 2026Peer-reviewedBiochemistry