Elad Elkayam

Identification and Validation of an inhibitor of the protein kinases PIM and DYRK

This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.

Novel small-molecule inhibitors of the protein kinase DYRK: Potential Therapeutic candidates in cancer

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

The molecular basis of Human FN3K mediated phosphorylation of glycated substrate

This study determines crystal structures of HsFN3K to elucidate its substrate recognition and kinase activity, providing insights for small molecule design targeting FN3K.