Ankur Garg

The paper reveals how structural dynamics between Ago2 and CK1α facilitate target RNA release during miRNA-mediated silencing through phosphorylation of the EI domain.

This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

This study investigates the structural and mechanistic role of Dis3L2 in RNA degradation, identifying a critical residue involved in double-stranded RNA processing.

This study determines crystal structures of HsFN3K to elucidate its substrate recognition and kinase activity, providing insights for small molecule design targeting FN3K.

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.