Leemor Joshua‐Tor

The paper compares origin recognition mechanisms in yeast and human cells, revealing evolutionary differences in DNA replication initiation.

The paper reveals how structural dynamics between Ago2 and CK1α facilitate target RNA release during miRNA-mediated silencing through phosphorylation of the EI domain.

The paper identifies POU2F1 as a key regulator of DLL3 and neuroendocrine identity in SCLC through CRISPR screens and epigenomic analysis.

This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.

The paper identifies a developmental timer in C. elegans that coordinates microRNA transcription across tissues through a feedback loop between MYRF-1 and LIN-42.

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

This study investigates the structural and mechanistic role of Dis3L2 in RNA degradation, identifying a critical residue involved in double-stranded RNA processing.

This study determines crystal structures of HsFN3K to elucidate its substrate recognition and kinase activity, providing insights for small molecule design targeting FN3K.

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

This study shows that miRNA Argonaute slicing has a minor role in star strand destabilization in C. elegans, with limited developmental impact and context-dependent effects.

The paper shows that DDM1 remodels histone H3 variants to facilitate epigenetic inheritance of DNA methylation by interacting with specific histone modifications and variants.

The paper shows that NHR-85 and NHR-23 heterodimers regulate lin-4 miRNA transcription pulses in C. elegans, similar to circadian clock mechanisms in mammals.

The paper identifies sequence-specificity in DNA replication origins mediated by Orc4 α-helix in S. cerevisiae and links its evolution to gene silencing mechanisms.