Patrick Sung

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

This study shows that phosphorylation of RAD51AP1 at S277/282 regulates its function in homology-directed DNA repair, with phosphomimetic variants enhancing its activity.

This paper maps 6,888 RAD51D variants to identify biochemical functions critical for homologous recombination and olaparib response, revealing key regions and mechanisms of variant impact.

This study identifies distinct roles of BRCA2's two DNA binding domains in DNA repair and replication fork stability using genetic and biochemical methods.

This study identifies TLK1-mediated phosphorylation of RAD54 at specific sites that regulate homologous recombination repair, with distinct effects on repair efficiency and cell survival.

This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.