P. J. Wolters

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

A fibroblast-derived TGFβ/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

The paper identifies SEL1L as a regulator of collagen turnover through a negative feedback loop, showing its role in limiting collagen accumulation in fibrotic lung disease.

Tetraose steroidal glycoalkaloids from potato provide resistance against Alternaria solani and Colorado potato beetle

This study identifies tetraose steroidal glycoalkaloids from Solanum commersonii that confer resistance against Alternaria solani and Colorado potato beetle, and show antifungal activity in vitro.

Double trouble or a blessing in disguise? Co-infection of potato with the causal agents of late and early blight

This study investigates how two potato pathogens, Alternaria solani and Phytophthora infestans, interact when co-infected, finding that A. solani inhibits P. infestans growth and infection in both lab and field settings.

Whole genome sequencing elucidates the species-wide diversity and evolution of fungicide resistance in the early blight pathogen Alternaria solani

This study uses whole-genome sequencing to analyze the genetic diversity and evolution of fungicide resistance in Alternaria solani across Europe, finding that SDHI resistance mutations arose independently in different genetic backgrounds.

RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes

This paper introduces RLP/KSeq, a method to rapidly map receptor-like protein (RLP) and receptor-like kinase (RLK) genes in plants, demonstrating its application in identifying PRRs in Solanum species.

Telomere Dysfunction Drives Chronic Lung Allograft Dysfunction Pathology

This study shows that telomere dysfunction in club cells causes lung remodeling and fibrosis similar to chronic lung allograft dysfunction in humans.

Reference-based annotation of single-cell transcriptomes identifies a profibrotic macrophage niche after tissue injury

The paper uses scRNA-seq to identify a profibrotic macrophage subtype in injured lung tissue, showing its role in fibrosis and potential as a therapeutic target.