Author

F. R. Papa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

B. J. Backes· 2 shared M. Thamsen· 2 shared A. Brumwell· 1 shared A. Hiniker· 1 shared A. Igbaria· 1 shared A. Trusina· 1 shared D. J. Maly· 1 shared D. Sheppard· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

B. J. Backes

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

V. C. Auyeung, M. S. Downey, J. J. Kathiriya, M. Thamsen, T. A. Wenger, B. J. Backes, A. Brumwell, H. A. Chapman, D. Sheppard, F. R. Papa

This study shows that IRE1α inhibition reduces ER stress and TGFβ signaling in lung epithelial cells, decreasing fibrosis by targeting damage-associated progenitors.

bioRxiv · Sep 16, 2021Cell Biology

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival

P. C. Moore, J. Y. Qi, M. Thamsen, R. Ghosh, J. Peng, M. J. Gliedt, R. Meza-Acevedo, R. E. Warren, A. Hiniker, G. E. Kim, D. J. Maly, B. J. Backes, F. R. Papa, S. A. Oakes

This study shows that targeting the UPR components IRE1α and PERK can inhibit pancreatic neuroendocrine tumor growth by inducing apoptosis through reciprocal signaling.

bioRxiv · Sep 18, 2019Cancer Biology

Chaperone-Mediated Reflux of Secretory Proteins to the Cytosol During Endoplasmic Reticulum Stress

A. Igbaria, P. I. Merksamer, A. Trusina, F. Tilahun, J. R. Johnson, O. Brandman, N. J. Krogan, J. S. Weissman, F. R. Papa

The paper identifies a chaperone-mediated process that refuxes properly folded ER proteins to the cytosol during ER stress, functioning parallel to ERAD.

bioRxiv · Mar 12, 2019Cell Biology