Author

K. C. Keiler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Assay:structural biology· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

C. M. Dunham· 2 shared J. N. Alumasa· 2 shared A. B. Kuzmishin Nagy· 1 shared A. E. Jerse· 1 shared A. Mehrani· 1 shared A. Nekrutenko· 1 shared D. Hosangadi· 1 shared D. Lariviere· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

C. M. Dunham

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

N. Marathe, H. A. Nguyen, J. N. Alumasa, A. B. Kuzmishin Nagy, M. Y. Vazquez, C. M. Dunham, K. C. Keiler

This paper identifies KKL-55, a tetrazole-based antibiotic that specifically inhibits EF-Tu binding to tmRNA without affecting tRNA binding, suggesting a new target for antibiotic development.

bioRxiv · Jun 9, 2023 · PreprintBiochemistry

Ribosome rescue inhibitors clear Neisseria gonorrhoeae in vivo using a new mechanism

Z. D. Aron, A. Mehrani, E. D. Hoffer, K. L. Connolly, M. C. Torhan, J. N. Alumasa, P. Srinivas, M. Cabrera, D. Hosangadi, J. S. Barbor, S. C. Cardinale, S. M. Kwasny, L. R. Morin, M. M. Butler, T. J. Opperman, , K. C. Keiler

The paper describes the development of ribosome rescue inhibitors that clear drug-resistant Neisseria gonorrhoeae in vivo through a novel mechanism involving ribosomal conformational changes.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology

Reproducible and accessible analysis of transposon insertion data at scale

D. Lariviere, L. Wickham, K. C. Keiler, A. Nekrutenko

The paper develops workflows and tools for analyzing TIS data using a public Galaxy platform and interactive tutorials to improve reproducibility and accessibility.

bioRxiv · May 19, 2020 · PreprintMicrobiology

A new mechanism for ribosome rescue can recruit RF1 or RF2 to non-stop ribosomes

T. D. Goralski, G. S. Kirimanjeswara, K. C. Keiler

This paper identifies ArfT as a new ribosome rescue factor in Francisella tularensis that functions with RF1 or RF2, distinct from known factors, and shows its role in rescuing non-stop ribosomes.

bioRxiv · Nov 8, 2018Microbiology