An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes
Shamitha Govind, Sebastian Ruppert, Joseph Kirangwa, Virginia Busetto, Emily Nischwitz, Miguel Vasconcelos Almeida, Svenja Hellmann, H. A. Witte, Ralf J. Sommer, Falk Butter, Sebastian Falk, Peter Sarkies, René F. Ketting
The paper shows that GTSF-1 binds RRF-3 in nematodes, a conserved interaction essential for 26G-RNA production and fertility.
EMBO Reports · Aug 29, 2026Peer-reviewedMolecular Biology