Svenja Hellmann

Phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance

This study shows that phosphorylation of Z granule components regulates germ granule organization and RNAi inheritance in C. elegans.

An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes

The paper shows that GTSF-1 binds RRF-3 in nematodes, a conserved interaction essential for 26G-RNA production and fertility.

Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins

The paper identifies a novel regulatory mechanism involving proteolytic processing of N-terminal intrinsically disordered regions in C. elegans Argonaute proteins, which controls small RNA selectivity and activity.

piRNA processing by a trimeric Schlafen-domain nuclease

The paper identifies PUCH, a trimeric Schlafen-domain nuclease that initiates piRNA processing in C. elegans by cleaving 5-end piRNA precursors, revealing a novel RNA endonuclease mechanism.

The IDR-containing protein PID-2 affects Z granules and is required for piRNA-induced silencing in the embryo

The paper identifies PID-2 and related proteins as essential for establishing and maintaining RNAe in C. elegans embryos through interactions with eTudor domain proteins and proteolysis.

PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability

The paper identifies PETISCO as a novel protein complex essential for 21U RNA biogenesis and embryonic viability in C. elegans, revealing its distinct roles from PID-1.