Miguel Vasconcelos Almeida

An Evolutionarily Conserved N-terminal Domain of RRF-3 Governs GTSF-1 Binding in Nematodes

The paper shows that GTSF-1 binds RRF-3 in nematodes, a conserved interaction essential for 26G-RNA production and fertility.

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory

This study identifies SET-24, a catalytically inactive SET domain protein in C. elegans, as essential for maintaining transgenerational epigenetic memory through its interaction with HCF-1 and regulation of H3K4me3 levels.

Transposable elements drive regulatory and functional innovation of F-box genes

The paper identifies recurrent capture of transposable element domains by F-box genes across eukaryotes and shows their functional integration into host regulatory networks.

Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes

The paper investigates the dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes, revealing expanded piwil1 genes and divergent piRNA-producing loci.

A pangenomic perspective of the Lake Malawi cichlid radiation reveals extensive structural variation driven by transposable elements

The paper uses a pangenomic approach to analyze Lake Malawi cichlid genomes, revealing extensive structural variation driven by transposable elements.

The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline

The paper identifies LOTR-1, a C. elegans protein with LOTUS and Tudor domains, which interacts with ZNFX-1 to regulate small RNA processing in the germline.

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways

The paper investigates maternal and zygotic gene regulatory effects of endogenous RNAi pathways in C. elegans, revealing how sRNA-Argonaute complexes influence gene silencing across generations.

RppH can faithfully replace TAP to allow cloning of 5’-triphosphate carrying small RNAs

The paper shows that RppH can replace TAP for small RNA library preparation, preserving 5’-triphosphate groups and maintaining comparable results.

GTSF-1 is required for the formation of a functional RNA-dependent RNA Polymerase complex in C. elegans

The paper identifies GTSF-1 as a protein required for the formation of an RNA-dependent RNA Polymerase complex in C. elegans, which is essential for 26G-RNA generation.