Author

H. C. Safford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

J. P. Straehla· 2 shared N. Boehnke· 2 shared P. T. Hammond· 2 shared A. G. Berger· 1 shared A. N. Koehler· 1 shared C. H. Adelmann· 1 shared C. Hajal· 1 shared D. Rosenberg· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioengineering

J. P. Straehla

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2 papers

Recent·Most cited

A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier penetrant nanoparticles

J. P. Straehla, C. Hajal, H. C. Safford, G. Offeddu, N. Boehnke, T. Dacoba, J. Wyckoff, R. D. Kamm, P. T. Hammond

This paper develops a microfluidic model of human glioblastoma to study nanoparticle trafficking across the blood-brain barrier and evaluates their therapeutic efficacy.

bioRxiv · Dec 7, 2021Bioengineering

Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions

N. Boehnke, J. P. Straehla, H. C. Safford, M. Kocak, M. G. Rees, M. Ronan, D. Rosenberg, C. H. Adelmann, R. R. Chivukula, N. Nabar, A. G. Berger, N. G. Lamson, J. H. Cheah, H. Li, J. A. Roth, , P. T. Hammond

The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.

bioRxiv · Apr 5, 2021 · PreprintBioengineering