Author

J. H. Cheah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

C. K. Soule· 3 shared A. Lopes· 2 shared G. Traverso· 2 shared J. A. Roth· 2 shared K. Ishida· 2 shared M. G. Rees· 2 shared A. Ali· 1 shared A. Deik· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

C. K. Soule

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics

G. W. Liu, M. J. Pickett, J. L. P. Kuosmanen, K. Ishida, W. A. M. Madani, G. N. White, J. Jenkins, V. R. Feig, M. Jimenez, A. Lopes, J. Morimoto, N. Fitzgerald, J. H. Cheah, C. K. Soule, N. Fabian, , G. Traverso

This paper develops LIFT hydrogels that form in the stomach to deliver drugs with controlled release, improving bioavailability and reducing toxicity.

bioRxiv · Dec 15, 2022 · PreprintBioengineering

Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions

N. Boehnke, J. P. Straehla, H. C. Safford, M. Kocak, M. G. Rees, M. Ronan, D. Rosenberg, C. H. Adelmann, R. R. Chivukula, N. Nabar, A. G. Berger, N. G. Lamson, J. H. Cheah, H. Li, J. A. Roth, , P. T. Hammond

The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.

bioRxiv · Apr 5, 2021 · PreprintBioengineering

Computationally guided high-throughput design of self-assembling drug nanoparticles

D. Reker, Y. Rybakova, A. R. Kirtane, R. Cao, J. W. Yang, N. Navamajiti, A. Gardner, R. M. Zhang, T. Esfandiary, J. L'Heureux, T. von Erlach, E. M. Smekalova, D. Leboeuf, K. Hess, A. Lopes, , G. Traverso

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

bioRxiv · Sep 30, 2019Bioengineering