Author

G. Offeddu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

C. Hajal· 3 shared L. Ibrahim· 2 shared R. D. Kamm· 2 shared R. Kamm· 2 shared Z. Wan· 2 shared C. Foley· 1 shared C. Zhang· 1 shared D. Barbie· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

C. Hajal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1R

H. T. Nguyen, N. Gurvich, M. R. Gillrie, G. Offeddu, M. Humayun, E. L. Kan, Z. Wan, M. F. Coughlin, C. Zhang, V. Vu, S. W. L. Lee, S.-L. Tan, D. Barbie, J. Hsu, R. D. Kamm

This paper develops a vascularized tumor model to study TAM recruitment and evaluates a multispecific antibody's effect on monocyte migration and TAM repolarization.

bioRxiv · Nov 28, 2023Bioengineering

A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier penetrant nanoparticles

J. P. Straehla, C. Hajal, H. C. Safford, G. Offeddu, N. Boehnke, T. Dacoba, J. Wyckoff, R. D. Kamm, P. T. Hammond

This paper develops a microfluidic model of human glioblastoma to study nanoparticle trafficking across the blood-brain barrier and evaluates their therapeutic efficacy.

bioRxiv · Dec 7, 2021Bioengineering

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform

C. Hajal, L. Ibrahim, J. C. Serrano, G. Offeddu, R. Kamm

This study examines how different fluid flows affect tumor cell extravasation and invasion in a 3D in vitro model, finding that luminal and trans-endothelial flows enhance these processes.

bioRxiv · Sep 23, 2020Cancer Biology

Glycocalyx-Mediated Vascular Dissemination of Circulating Tumor Cells

G. Offeddu, C. Hajal, C. Foley, Z. Wan, L. Ibrahim, M. Coughlin, R. Kamm

This study shows tumor cells use glycocalyx components to adhere to endothelium and invade stroma, suggesting targeting this pathway could reduce metastasis.

bioRxiv · Apr 28, 2020Cancer Biology