Author

J. P. Straehla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

P. T. Hammond· 4 shared H. C. Safford· 2 shared J. Wyckoff· 2 shared N. Boehnke· 2 shared N. G. Lamson· 2 shared A. G. Berger· 1 shared A. J. Pickering· 1 shared A. N. Koehler· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBioengineering

P. T. Hammond

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Author profile →

4 papers

Recent·Most cited

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

E. L. Cheng, S. Pal, J. W. Tsai, C. B. Yampanis, S. Rangaswamy, J. Kenny-Serrano, M. Coppola, M. Ozdemir, K. Y. Cai, E. VanGosen, E. Bateman, K. R. Bennett, M. M. Billingsley, C. A. Whittaker, Y. Zhang, , J. P. Straehla

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

bioRxiv · Sep 11, 2026 · PreprintBioengineering

Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models

N. G. Lamson, A. J. Pickering, J. Wyckoff, P. Ganesh, J. P. Straehla, P. T. Hammond

This study shows that nanoparticle core stiffness and surface chemistry independently affect uptake, transport, and trafficking across the blood-brain barrier in vitro and in vivo.

bioRxiv · Oct 31, 2022 · PreprintBioengineering

A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier penetrant nanoparticles

J. P. Straehla, C. Hajal, H. C. Safford, G. Offeddu, N. Boehnke, T. Dacoba, J. Wyckoff, R. D. Kamm, P. T. Hammond

This paper develops a microfluidic model of human glioblastoma to study nanoparticle trafficking across the blood-brain barrier and evaluates their therapeutic efficacy.

bioRxiv · Dec 7, 2021Bioengineering

Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions

N. Boehnke, J. P. Straehla, H. C. Safford, M. Kocak, M. G. Rees, M. Ronan, D. Rosenberg, C. H. Adelmann, R. R. Chivukula, N. Nabar, A. G. Berger, N. G. Lamson, J. H. Cheah, H. Li, J. A. Roth, , P. T. Hammond

The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.

bioRxiv · Apr 5, 2021 · PreprintBioengineering