Author

C. H. Adelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. M. Sabatini· 2 shared A. G. Berger· 1 shared A. N. Koehler· 1 shared D. Rosenberg· 1 shared H. C. Safford· 1 shared H. Li· 1 shared H. R. Keys· 1 shared J. A. Roth· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

D. M. Sabatini

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Author profile →

3 papers

Recent·Most cited

Massively parallel pooled screening reveals genomic determinants of nanoparticle-cell interactions

N. Boehnke, J. P. Straehla, H. C. Safford, M. Kocak, M. G. Rees, M. Ronan, D. Rosenberg, C. H. Adelmann, R. R. Chivukula, N. Nabar, A. G. Berger, N. G. Lamson, J. H. Cheah, H. Li, J. A. Roth, , P. T. Hammond

The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.

bioRxiv · Apr 5, 2021 · PreprintBioengineering

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

K. J. Condon, J. M. Orozco, C. H. Adelmann, J. B. Spinelli, P. W. van der Helm, J. M. Roberts, T. Kunchok, D. M. Sabatini

This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.

bioRxiv · Oct 22, 2020Cell Biology

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

N. J. Rossiter, K. S. Huggler, C. H. Adelmann, H. R. Keys, R. W. Soens, D. M. Sabatini, J. R. Cantor

This study uses CRISPR screens in different media to identify conditionally essential genes in human cells, showing how medium composition affects gene essentiality.

bioRxiv · Aug 31, 2020Cancer Biology