Author

H. D. Skinner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. R. Pickering· 3 shared J. N. Myers· 3 shared A. Hefner· 2 shared B. Beadle· 2 shared D. Molkentine· 2 shared J. Molkentine· 2 shared L. Yang· 2 shared M. Abdelhakiem· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

C. R. Pickering

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3 papers

Recent·Most cited

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

P. M. Pifer, L. Yang, M. Kumar, T. Xie, M. Frederick, A. Hefner, B. Beadle, D. Molkentine, J. Molkentine, A. Dhawan, M. Abdelhakiem, A. A. Osman, J. N. Myers, C. R. Pickering, V. C. Sandulache, , H. D. Skinner

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

bioRxiv · Jun 3, 2022Cancer Biology

Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis

B. Uzunparmak, M. Gao, A. Lindemann, K. Erikson, L. Wang, E. Lin, S. Frank, F. O. Gleber-Netto, M. Zhao, H. D. Skinner, J. Newton, A. G. Sikora, J. N. Myers, C. R. Pickering

This study shows that loss of CASP8 function combined with SMAC mimetic treatment increases necroptosis in HNSCC, enhancing radiation sensitivity.

JCI Insight · Dec 3, 2020Peer-reviewedCancer Biology

Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function.

M. Kumar, D. Molkentine, J. Molkentine, K. Bridges, T. Xie, L. Yang, A. Hefner, M. Gao, M. J. Frederick, S. Seth, M. Abdelhakiem, B. Beadle, F. M. Johnson, J. Wang, L. Shen, , H. D. Skinner

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

bioRxiv · Apr 10, 2020 · PreprintCancer Biology