Author

H. E. Bullen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. S. Crabb· 4 shared P. R. Gilson· 4 shared B. E. Sleebs· 2 shared M. G. Dans· 2 shared O. Looker· 2 shared S. C. Charnaud· 2 shared A. E. Barry· 1 shared B. Elsworth· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMicrobiology

B. S. Crabb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivApr 25, 2023

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.

D. B. Ling, W. Nguyen, O. Looker…·P. R. Gilson

The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.

DOI 10.1021/acsinfecdis.3c00138

plant (other)experimental assay

MicrobiologybioRxivPreprintNov 15, 2022

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum.

T. K. Jonsdottir, B. Elsworth, S. Cobbold…·P. R. Gilson

This study identifies PTEX150 as essential for trafficking haemoglobinases to the food vacuole in Plasmodium falciparum, revealing a new metabolic function for PTEX beyond the known permeability pathway.

DOI 10.1101/2022.11.15.516562

humanproteomics

BiochemistrybioRxivMay 1, 2022

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

O. Looker, M. G. Dans, H. E. Bullen…·P. R. Gilson

The paper screens 400 anti-malarial compounds to identify inhibitors of protein export in Plasmodium falciparum, finding MMV396797 as a potent inhibitor that reduces parasite virulence.

DOI 10.1111/tra.12862

humanproteomics

MicrobiologybioRxivSep 17, 2018

Knockdown of the translocon protein EXP2, reduces growth and protein export in malaria parasites.

P. R. Gilson, S. C. Charnaud, R. Kumarasingha…·B. S. Crabb

This study shows that knocking down EXP2 in malaria parasites reduces growth and protein export, suggesting EXP2 is essential for the PTEX translocon's function in exporting proteins into host cells.

DOI 10.1371/journal.pone.0204785

humanproteomics