Author

M. G. Dans

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Organism:plant (other)· 1

Frequent Co-Authors

P. R. Gilson· 5 shared B. S. Crabb· 4 shared B. E. Sleebs· 3 shared C. Boulet· 2 shared G. E. Weiss· 2 shared H. E. Bullen· 2 shared T. F. de Koning-Ward· 2 shared T. K. Jonsdottir· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCell Biology

P. R. Gilson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

M. G. Dans, C. Boulet, G. M. Watson, W. Nguyen, J. M. Dziekan, C. Evelyn, K. Reaksudsan, S. Mehra, Z. Razook, N. D. Geoghegan, M. J. Mlodzianoski, C. D. Goodman, D. B. Ling, T. K. Jonsdottir, J. Tong, , P. R. Gilson

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

G. E. Weiss, R. J. Ragotte, D. Quinkert, A. M. Lias, M. G. Dans, C. Boulet, B. G. Williams, B. S. Crabb, S. J. Draper, P. R. Gilson

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum.

T. K. Jonsdottir, B. Elsworth, S. Cobbold, M. Gabriela, S. C. Charnaud, M. G. Dans, M. Parkyn Schneider, M. McConville, H. E. Bullen, B. S. Crabb, P. R. Gilson

This study identifies PTEX150 as essential for trafficking haemoglobinases to the food vacuole in Plasmodium falciparum, revealing a new metabolic function for PTEX beyond the known permeability pathway.

bioRxiv · Nov 15, 2022 · PreprintMicrobiology

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

O. Looker, M. G. Dans, H. E. Bullen, B. E. Sleebs, B. S. Crabb, P. R. Gilson

The paper screens 400 anti-malarial compounds to identify inhibitors of protein export in Plasmodium falciparum, finding MMV396797 as a potent inhibitor that reduces parasite virulence.

bioRxiv · May 1, 2022Biochemistry

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

M. G. Dans, G. E. Weiss, D. W. Wilson, B. E. Sleebs, B. Crabb, T. F. de Koning-Ward, P. R. Gilson

The paper screens a compound library to identify inhibitors of Plasmodium falciparum egress and invasion, finding several compounds with specific inhibitory effects.

bioRxiv · Sep 13, 2019Cell Biology