Fingerprint SRS Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans
M. Zhang, P.-T. Dong, H. E. Eldesouky, Y. Zhan, H. Lin, Z. Wang, E. A. Salama, S. Jusuf, C. Zong, Z. Chen, M. N. Seleem, J.-X. Cheng
This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.
bioRxiv · Dec 9, 2022 · PreprintMicrobiology