Author

P.-T. Dong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:proteomics· 3 Organism:bacteria (other)· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2

Frequent Co-Authors

J. Hui· 5 shared J.-X. Cheng· 5 shared S. Jusuf· 5 shared Y. Zhan· 4 shared G. Y. Liu· 3 shared C. Zong· 2 shared E. R. Ulloa· 2 shared J. Li· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersMicrobiology

J. Hui

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Antimicrobial blue light-bathing therapy for wound infection control

J. Hui, W. Moon, P.-T. Dong, C. dos Anjos, L. Negri, H. Yan, Y. Wang, J. Tam, T. Dai, R. R. Anderson, J. Goverman, J. Gelfand, S.-H. Yun

This study introduces a low-irradiance blue light therapy for wound infections, showing it effectively reduces bioburden while being safer than high-irradiance methods.

bioRxiv · Apr 13, 2024 · PreprintBioengineering

Episymbiotic bacterium induces intracellular lipid droplet production in its host bacteria

P.-T. Dong, J. Tian, K. J. Kobayashi-Kirschvink, L. Cen, J. S. McLean, B. Bor, W. Shi, X. He

This study investigates the interaction between Saccharibacteria TM7x and its host XH001, revealing TM7x-induced lipid droplet formation in XH001 and its protective role under stress.

bioRxiv · Sep 6, 2023 · PreprintMicrobiology

Fingerprint SRS Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans

M. Zhang, P.-T. Dong, H. E. Eldesouky, Y. Zhan, H. Lin, Z. Wang, E. A. Salama, S. Jusuf, C. Zong, Z. Chen, M. N. Seleem, J.-X. Cheng

This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.

bioRxiv · Dec 9, 2022 · PreprintMicrobiology

Targeting Fusobacterium nucleatum through Chemical Modifications of Host-Derived Transfer RNA Fragments

M. Yang, P.-T. Dong, L. Cen, W. Shi, X. He, J. Li

The paper chemically modifies host-derived tRNA fragments to selectively inhibit Fusobacterium nucleatum with nanomolar efficacy, while sparing other oral bacteria.

bioRxiv · Sep 29, 2022Bioengineering

Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells

P.-T. Dong, Y. Zhan, S. Jusuf, J. Hui, Z. Dagher, M. K. Mansour, J.-X. Cheng

This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.

bioRxiv · Aug 31, 2021Microbiology

Photoinactivation of Catalase Sensitizes Wide-Ranging Bacteria to ROS-Producing Agents and Immune Cells

P.-T. Dong, S. Jusuf, J. Hui, Y. Zhan, Y. Zhu, G. Y. Liu, J.-X. Cheng

This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.

bioRxiv · Jun 24, 2021Microbiology

Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae

S. Jusuf, P.-T. Dong, J. Hui, E. R. Ulloa, G. Y. Liu, J.-X. Cheng

This study shows that photobleaching granadaene in Streptococcus agalactiae reduces its virulence and increases antimicrobial susceptibility to antibiotics and macrophage killing.

bioRxiv · Mar 31, 2020Microbiology

Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA

J. Hui, P.-T. Dong, L. Liang, T. Mandal, J. Li, E. R. Ulloa, Y. Zhan, S. Jusuf, C. Zong, M. N. Seleem, G. Y. Liu, Q. Cui, J.-X. Cheng

This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.

bioRxiv · Sep 26, 2019Microbiology