Author

H. E. Grimsley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

J. Cinatl· 2 shared M. Michaelis· 2 shared A. Nist· 1 shared C. Harper-Wynne· 1 shared C. Hsu· 1 shared D. Speidel· 1 shared I. G. Reddin· 1 shared I. R. Brown· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

J. Cinatl

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Author profile →

2 papers

Recent·Most cited

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

H. E. Grimsley, M. Antczak, I. G. Reddin, K.-M. McLaughlin, A. Nist, M. Mernberger, T. Stiewe, T. R. Fenton, D. Speidel, C. Harper-Wynne, K. Cox, J. Cinatl, M. N. Wass, M. Garrett, M. Michaelis

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

bioRxiv · Jan 20, 2024 · PreprintCancer Biology

A novel exosome biogenesis mechanism: multivesicular structures budding and rupturing at the plasma membrane

S. Leon Quinonez, I. R. Brown, H. E. Grimsley, J. Cinatl, M. Michaelis, C. Hsu

The paper identifies a novel exosome release mechanism where multivesicular structures protrude from the plasma membrane and rupture to release exosomes, distinct from the conventional multivesicular endosome fusion process.

bioRxiv · Nov 21, 2019 · PreprintCell Biology