Author

H. E. Humphries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:rat· 2 Research Focus:spatial domain detection· 2 Organism:chicken / avian· 1

Frequent Co-Authors

K. A. Ryan· 4 shared Y. Hall· 4 shared D. Ngabo· 3 shared E. Brunt· 3 shared F. J. Salguero· 3 shared J. Paterson· 3 shared K. E. Gooch· 3 shared K. R. Bewley· 3 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

K. A. Ryan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

K. A. Ryan, K. R. Bewley, S. A. Fotheringham, P. Brown, Y. Hall, A. C. Marriott, J. A. Tree, L. Allen, M. J. Aram, E. Brunt, K. R. Buttigieg, B. E. Cavell, D. P. Carter, R. Cobb, N. S. Coombes, , M Dennis

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

Nature Communications · Jan 4, 2021Peer-reviewedMicrobiology

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S. Rauch, K. E. Gooch, Y. Hall, F. J. Salguero, M. J. Dennis, F. V. Gleeson, D. Harris, C. Ho, H. E. Humphries, S. Longet, D. Ngabo, J. Paterson, E. L. Rayner, K. A. Ryan, S. Sharpe, , M. W. Carroll

This study shows that the mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 infection and reduces disease severity.

bioRxiv · Dec 23, 2020 · PreprintImmunology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19.

F. J. Salguero, A. D. White, G. S. Slack, S. A. Fotheringham, K. R. Bewley, K. E. Gooch, S. Longet, H. E. Humphries, R. J. Watson, L. Hunter, K. A. Ryan, Y. Hall, L. Sibley, C. Sarfas, L. Allen, , Tr

This study compares rhesus and cynomolgus macaques as models for mild to moderate COVID-19, showing similar viral replication, immune responses, and histopathology.

bioRxiv · Sep 17, 2020Microbiology