Author

S. Rauch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:mouse· 6 Research Focus:drug response / drug discovery· 4 Organism:rat· 3 Organism:non-human primate· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Petsch· 7 shared N. Roth· 7 shared S. O. Mueller· 5 shared D. Hoffmann· 4 shared A. Dorhoi· 3 shared B. Corleis· 3 shared C. Fricke· 3 shared J. Gergen· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

B. Petsch

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

F. Costacurta, A. Dodaro, D. Bante, H. Schoeppe, B. Sprenger, S. A. Moghadasi, J. Fleischmann, M. Pavan, D. Bassani, S. Menin, S. Rauch, L. Krismer, A. Sauerwein, A. Heberle, T. Rabensteiner, , E. Heilmann

This study identifies and characterizes SARS-CoV-2 Mpro mutations conferring resistance to nirmatrelvir using a VSV-based system and biochemical assays.

bioRxiv · Sep 22, 2023Microbiology

Novel mRNA-based VP8* vaccines against rotavirus are highly immunogenic in rodents

S. Roier, V. M. Prasad, M. M. McNeal, K. K. Lee, B. Petsch, S. Rauch

This study develops mRNA-based VP8* vaccines against rotavirus, showing immunogenicity in rodents with LS-P2-VP8* inducing superior humoral responses.

bioRxiv · Mar 29, 2023Immunology

Assessment of Immunogenicity and Efficacy of CV0501 mRNA-based Omicron COVID-19 Vaccination in Small Animal Models

N. Roth, J. Gergen, K. Kovacikova, S. Mueller, L. Ulrich, J. Schoen, N. J. Halwe, C. Fricke, B. Corleis, A. Dorhoi, D. Hoffmann, M. Beer, D. Maione, B. W. Petsch, S. Rauch

This paper evaluates the immunogenicity and efficacy of a bivalent mRNA vaccine CV0501 against Omicron subvariants in animal models, showing robust neutralizing antibodies and reduced viral loads.

bioRxiv · Jan 4, 2023Immunology

Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

B. Corleis, D. Hoffmann, S. Rauch, C. Fricke, N. Roth, J. Gergen, K. Kovacikova, K. Schlottau, N. J. Halwe, L. Ulrich, J. Schön, K. Wernike, M. Widera, S. Ciesek, S. O. Mueller, , A. Dorhoi

This study shows a low-dose bivalent mRNA vaccine targeting multiple SARS-CoV-2 variants provides strong protection in mice and rats, with comparable antibody levels and reduced viral replication.

bioRxiv · Apr 20, 2022 · PreprintImmunology

mRNA Vaccines Induce Rapid Antibody Responses in Mice

M. Gebre, S. Rauch, N. Roth, J. Gergen, J. Yu, X. Liu, A. Cole, S. Mueller, B. W. Petsch, D. H. Barouch

This study shows mRNA vaccines induce rapid antibody responses in mice by day 5, outperforming DNA, protein, and adenovirus vaccines for SARS-CoV-2 and HIV-1 antigens.

bioRxiv · Nov 1, 2021Microbiology

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

M. Gebre, S. Rauch, N. Roth, J. Yu, A. Chandrashekar, N. Mercado, X. He, J. Liu, K. McMahan, A. Martinot, T. Giffin, D. Hope, S. Patel, D. Sellers, O. Sanborn, , D. H. Barouch

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

bioRxiv · Aug 13, 2021 · PreprintImmunology

Optimised non-coding regions of mRNA SARS-CoV-2 vaccine CV2CoV improves homogeneous and heterogenous neutralising antibody responses

N. Roth, J. Schoen, D. Hoffmann, M. Thran, A. Thess, S. O. Mueller, B. Petsch, S. Rauch

This study compares two mRNA vaccines, CVnCoV and CV2CoV, showing CV2CoV induces higher neutralizing antibody titers and cross-neutralization against variants in rats.

bioRxiv · May 13, 2021 · PreprintImmunology

CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

D. Hoffmann, B. Corleis, S. Rauch, N. Roth, J. Muehe, N. J. Halwe, L. Ulrich, C. Fricke, J. Schoen, A. Kraft, A. Breithaupt, K. Wernike, A. Michelitsch, F. Sick, C. Wylezich, , M. Beer

This study evaluates the efficacy of the CVnCoV mRNA vaccine against ancestral and emerging SARS-CoV-2 variants in a human ACE2 transgenic mouse model, showing complete protection against B.1.351.

bioRxiv · Mar 22, 2021Microbiology

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S. Rauch, K. E. Gooch, Y. Hall, F. J. Salguero, M. J. Dennis, F. V. Gleeson, D. Harris, C. Ho, H. E. Humphries, S. Longet, D. Ngabo, J. Paterson, E. L. Rayner, K. A. Ryan, S. Sharpe, , M. W. Carroll

This study shows that the mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 infection and reduces disease severity.

bioRxiv · Dec 23, 2020 · PreprintImmunology

mRNA based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus neutralizing antibodies and mediates protection in rodents

S. Rauch, N. Roth, K. Schwendt, M. Fotin-Mleczek, S. O. Mueller, B. Petsch

This study shows that the mRNA vaccine CVnCoV induces strong neutralizing antibodies and protects hamsters from SARS-CoV-2 infection.

bioRxiv · Oct 23, 2020Immunology