Author

L. Allen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:non-human primate· 2 Organism:rat· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

E. Brunt· 3 shared H. E. Humphries· 3 shared K. A. Ryan· 3 shared K. R. Bewley· 3 shared L. Hunter· 3 shared P. Brown· 3 shared R. Cobb· 3 shared S. Leung· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. Brunt

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

C. N. Pacyna, M. Anandapadamanaban, K. W. Loudon, I. M. Hay, O. Perisic, R. Li, M. Byrne, L. Allen, K. Roberts, Y. Hooks, A. Y. Warren, G. D. Stewart, M. R. Clatworthy, S. Teichmann, S. Behjati, , T. J. Mitchell

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

bioRxiv · Dec 12, 2023Cancer Biology

A time and single-cell resolved model of hematopoiesis

I. Kucinski, J. Campos, M. Barile, F. Severi, N. Bohin, P. N. Moreira, L. Allen, H. Lawson, M. L. R. Haltalli, S. J. Kinston, D. O'Carroll, K. R. Kranc, B. Göttgens

The paper builds a real-time, quantitative model of hematopoiesis using time-series single-cell RNA-Seq and persistent labeling, revealing lineage-specific self-renewal and differentiation properties.

bioRxiv · Sep 7, 2022 · PreprintCell Biology

A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens

S. Price, S. G. Bhosle, E. Goncalves, X. Li, D. McClurg, A. Barthorpe, A. Beck, C. Hall, H. Lightfoot, L. Farrow, R. Ansari, D. A. Jackson, L. Allen, K. Roberts, C. Beaver, , M. Garnett

This paper introduces a suspension culture technique for cancer organoids that improves expansion efficiency and enables large-scale perturbation screens.

bioRxiv · Oct 23, 2021Cancer Biology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

Comparison of Rhesus and Cynomolgus macaques as an authentic model for COVID-19.

F. J. Salguero, A. D. White, G. S. Slack, S. A. Fotheringham, K. R. Bewley, K. E. Gooch, S. Longet, H. E. Humphries, R. J. Watson, L. Hunter, K. A. Ryan, Y. Hall, L. Sibley, C. Sarfas, L. Allen, , Tr

This study compares rhesus and cynomolgus macaques as models for mild to moderate COVID-19, showing similar viral replication, immune responses, and histopathology.

bioRxiv · Sep 17, 2020Microbiology

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

K. A. Ryan, K. R. Bewley, S. A. Fotheringham, P. Brown, Y. Hall, A. C. Marriott, J. A. Tree, L. Allen, M. J. Aram, E. Brunt, K. R. Buttigieg, B. E. Cavell, D. P. Carter, R. Cobb, N. S. Coombes, , M Dennis

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

bioRxiv · May 29, 2020Microbiology