Author

J. R. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:long-read sequencing· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. H. Gundlach· 4 shared J. M. Craig· 4 shared H. C. Kim· 3 shared S. J. Abell· 3 shared A. H. Laszlo· 2 shared J. W. Mount· 2 shared A. Laszlo· 1 shared A. M. Pfeffer· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiophysics

J. H. Gundlach

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4 papers

Recent·Most cited

Nanopore molecular trajectories of a eukaryotic reverse transcriptase reveal a long-range RNA structure sensing mechanism

A. Shaw, J. M. Craig, H. Amiri, J. Kim, H. E. Upton, S. C. Pimentel, J. R. Huang, S. Marqusee, J. H. Gundlach, K. Collins, C. J. Bustamante

The paper uses nanopore sequencing to study the single-nucleotide kinetics of a reverse transcriptase, revealing its ability to sense and destabilize RNA structures during cDNA synthesis.

bioRxiv · Apr 5, 2023 · PreprintBiophysics

Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution.

S. K. Marx, K. J. Mickolajczyk, J. M. Craig, C. A. Thomas, A. M. Pfeffer, S. J. Abell, J. D. Carrasco, M. C. Franzi, J. R. Huang, H. C. Kim, H. D. Brinkerhoff, T. M. Kapoor, J. H. Gundlach, A. H. Laszlo

This study uses nanopore tweezers to analyze SARS-CoV-2 helicase nsp13 motion and inhibition at single-nucleotide resolution, revealing kinetic mechanisms and inhibitor effects.

bioRxiv · Oct 7, 2022 · PreprintBiophysics

Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution.

A. H. Laszlo, J. M. Craig, M. Gavrilov, R. Tippana, I. C. Nova, J. R. Huang, H. C. Kim, S. J. Abell, M. deCampos-Stairiker, J. W. Mount, J. L. Bowman, K. S. Baker, H. Higinbotham, D. Bobrovnikov, T. Ha, J. H. Gundlach

This study uses SPRNT to analyze how DNA sequence affects PcrA helicase kinetics during translocation and unwinding at single-nucleotide resolution.

bioRxiv · Feb 10, 2022Biophysics

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion

J. M. Craig, M. Mills, A. Laszlo, H. C. Kim, S. J. Abell, J. R. Huang, J. W. Mount, K. C. Neuman, J. H. Gundlach

This study uses Nanopore Tweezers to measure RecQ helicase conformational changes, revealing an asymmetric energy landscape that allows it to maintain speed against opposing forces.

bioRxiv · Sep 23, 2021Biophysics