H. Harvey

Metabolic connections between folate and peptidoglycan pathways in Pseudomonas aeruginosa inform rational design of a dual-action inhibitor

This study identifies metabolic links between folate and peptidoglycan pathways in Pseudomonas aeruginosa and uses these insights to design a dual-action inhibitor that overcomes antibiotic resistance.

A genetic screen identifies a role for oprF in Pseudomonas aeruginosa biofilm stimulation by subinhibitory antibiotics

This paper identifies OprF and SigX as key factors in sub-MIC antibiotic-induced biofilm formation in Pseudomonas aeruginosa, linking periplasmic redox changes to c-di-GMP signaling.

Nutrient Limitation Sensitizes Pseudomonas aeruginosa to Vancomycin

This study shows that vancomycin inhibits Pseudomonas aeruginosa growth under nutrient limitation and identifies resistance mechanisms linked to LPS biosynthesis and CpxSR signaling.

Extracellular release of mitochondrial DNA is triggered by cigarette smoke and is detected in COPD

This study shows that cigarette smoke triggers mitochondrial DNA release in COPD patients and animal models, linking it to inflammation and disease progression.

Exploration of BAY 11-7082 as a novel antibiotic

The paper identifies BAY 11-7082 as a molecule that stimulates biofilm formation in Pseudomonas aeruginosa and inhibits growth of MRSA and other pathogens, with analogues showing enhanced anti-Staphylococcal activity.

Pseudomonas aeruginosa TfpW is a multifunctional D-Araf glycosyltransferase and oligosaccharyltransferase

This paper identifies TfpW as a multifunctional enzyme in Pseudomonas aeruginosa that performs glycosylation, translocation, and polymerization of D-Araf in type IV pili.

Thiostrepton hijacks pyoverdine receptors to inhibit growth of Pseudomonas aeruginosa

This paper identifies thiostrepton's activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii under iron-limited conditions by exploiting pyoverdine receptors.

Bacteria defend against phages through type IV pilus glycosylation

This study shows that glycosylation of type IV pili in Pseudomonas aeruginosa protects against phage infection by masking binding sites, and identifies phage tail proteins that enable infection of glycosylated pili.

cAMP-Independent Control Of Twitching Motility In Pseudomonas aeruginosa

This study shows FimV regulates twitching motility in Pseudomonas aeruginosa independently of cAMP, through polar localization of regulatory proteins and structural components.

The type IVa pilus machinery is pre-installed during cell division

This study shows that the T4aP machinery is pre-installed at future cell division sites in P. aeruginosa without requiring dedicated peptidoglycan hydrolases.