Author

H. Hirai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1

Frequent Co-Authors

A. Konno· 2 shared A. Asiminas· 1 shared A. Sakai· 1 shared A. Takashima· 1 shared C. Delle· 1 shared C. T. Vo· 1 shared D. Yoshino· 1 shared H. Hirase· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

A. Konno

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation

X. Wang, C. Delle, A. Asiminas, S. Akther, M. Vittani, P. Brogger, P. Kusk, C. T. Vo, A. Konno, H. Hirai, M. Fukuda, P. Weikop, S. A. Goldman, M. Nedergaard, H. Hirase

This paper introduces a method to chronically image blood microcirculation using liver-secreted fluorescent proteins, enabling long-term observation of vascular functions in mice.

bioRxiv · Apr 8, 2022Physiology

Mis6/CENP-I maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis

H. Hirai, Y. Shogaki, M. Sato

This study shows that Mis6/CENP-I prevents loss of CENP-A nucleosomes at centromeres during mitosis by blocking non-coding transcription.

bioRxiv · Nov 3, 2021 · PreprintCell Biology

Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain

A. Sakai, T. Yasui, M. Watanave, R. Tatsumi, Y. Yamamoto, W. Takano, Y. Tani, I. Okamura, H. Hirai, S. Takeda, S. Takeda

This study identifies novel GPR85 inverse-agonists with IC50 values around 1 µM and shows they modulate potassium channel opening in cerebellar Purkinje cells.

bioRxiv · Sep 18, 2021Pharmacology & Toxicology

Antihypertensive effect of brain-targeted mechanical intervention with passive head motion

S. Murase, N. Sakitani, T. Maekawa, D. Yoshino, K. Takano, A. Konno, H. Hirai, T. Saito, S. Tanaka, K. Shinohara, T. Kishi, Y. Yoshikawa, T. Sakai, M. Ayaori, H. Inanami, , Y. Sawada

Passive head motion reduces blood pressure in hypertensive rats and humans by decreasing AT1R expression in RVLM astrocytes through interstitial fluid shear stress.

bioRxiv · Sep 21, 2020Bioengineering