Author

H. J. Melichar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

M.-E. Lebel· 2 shared A. Cotton· 1 shared A. J. Martins· 1 shared A. Obermayer· 1 shared A. Sood· 1 shared B. Assaf· 1 shared C. A. Bonkoungou· 1 shared C. Capdevielle· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

M.-E. Lebel

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Author profile →

4 papers

Recent·Most cited

CD271 restrains the B1b cell antibody response in a T cell dependent manner

M.-E. Lebel, C. A. Bonkoungou, J. Thibault, J. Rauch, K. R. Alugupalli, H. J. Melichar

This study shows CD271 restrains B1b cell antibody responses to T cell-independent antigens by maintaining CD4+ T cell quiescence and inhibiting T cell activity, similar to PD-L1.

bioRxiv · Jan 8, 2024 · PreprintImmunology

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax

M. Neault, C.-E. Lebert-Ghali, M. Fournier, C. Capdevielle, E. A. R. Garfinkle, A. Obermayer, A. Cotton, K. Boulay, C. Sawchyn, K. H. Nguyen, B. Assaf, F. E. Mercier, J.-S. Delisle, E. A. Drobetsky, L. Hulea, , F. A. Mallette

This study identifies GLIS2 as a driver of pediatric AMKL and shows its sensitivity to navitoclax, offering a potential therapeutic strategy.

Cell Reports · Sep 1, 2023Peer-reviewedCancer Biology

Predicting T cell activation based on intracellular calcium fluctuations

S. This, S. Costantino, H. J. Melichar

This paper uses deep learning to predict T cell antigen specificity from intracellular calcium fluctuations, offering a faster alternative to traditional methods.

bioRxiv · Jun 14, 2023 · PreprintImmunology

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

D. Rogers, A. Sood, H. Wang, J. J. P. van Beek, T. J. Rademaker, P. Artusa, C. Schneider, C. Shen, D. C. Wong, M.-E. Lebel, S. A. Condotta, M. J. Richer, A. J. Martins, J. S. Tsang, L. Barreiro, , J. N. Mandl

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

bioRxiv · Apr 21, 2021Immunology