J. S. Tsang

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Multiparameter stimulation mapping of signaling states in single pediatric immune cells reveals heightened tonic activation during puberty

The paper introduces HDStIM, an unsupervised method to analyze single-cell stimulation responses, revealing increased tonic activation in immune cells during puberty.

Contrasting autoimmune and treatment effects reveals baseline set points of immune toxicity following checkpoint inhibitor treatment

The paper identifies pre-treatment immune signatures associated with immune-related adverse events (irAEs) in thymic cancer patients receiving checkpoint inhibitors using CITE-seq.

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice

The paper develops a machine learning model using blood gene expression data to predict lethality in mice infected with influenza A virus.