Author

H. L. Malech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:CITE-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Sheikali· 1 shared B. Palterer· 1 shared C. A. Vakulskas· 1 shared C. L. Gardner· 1 shared C. L. Sweeney· 1 shared D. F. Stroncek· 1 shared D. S. Goldstein· 1 shared E. M. H. Gonzalez· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Sheikali

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Genetically Corrected RAG2-SCID Human Hematopoietic Stem CellsRestore V(D)J-Recombinase and Rescue Lymphoid Deficiency

M. Pavel-Dinu, C. L. Gardner, Y. Nakauchi, T. Kawai, O. M. Delmonte, B. Palterer, M. Bosticardo, F. Pala, S. Viel, H. L. Malech, H. Y. Ghanim, N. N. Bode, G. L. Kurgan, C. A. Vakulskas, A. Sheikali, , M. H. Porteus

This study corrects the RAG2 gene in human hematopoietic stem cells to restore V(D)J recombination and lymphoid development in RAG2-SCID patients.

bioRxiv · Jul 12, 2022Immunology

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells

N. Tamaoki, S. Siebert, T. Maeda, N.-H. Ha, M. L. Good, Y. Huang, S. K. Vodnala, J. J. H. Mora, U. Naoya, J. F. Tisdale, C. L. Sweeney, U. Choi, J. Brault, S. Koontz, H. L. Malech, , R. Vizcardo

This study develops yolk sac-like organoids from hiPSCs to generate multipotent hematopoietic progenitor cells in a scalable and xeno-free system.

bioRxiv · Apr 25, 2021Cell Biology