Author

Y. Nakauchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

M. H. Porteus· 2 shared M. Pavel-Dinu· 2 shared R. Majeti· 2 shared A. Awani· 1 shared A. DeVilbiss· 1 shared A. J. Gentles· 1 shared A. P. Boss· 1 shared A. Sheikali· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

M. H. Porteus

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AML/T cell interactomics uncover correlates of patient outcomes and the key role of ICAM1 in T cell killing of AML

E. C. Sayitoglu, B. A. Luca, A. P. Boss, B. C. Thomas, R. A. Freeborn, M. J. Uyeda, P. P. Chen, Y. Nakauchi, C. Waichler, N. J. Lacayo, R. Bacchetta, R. Majeti, A. J. Gentles, A.-M. Cepika, M. G. Roncarolo

The paper identifies ICAM1 as a key factor in T cell killing of AML by analyzing transcriptional programs in AML and T cell interactions.

bioRxiv · Sep 21, 2023Immunology

Genetically Corrected RAG2-SCID Human Hematopoietic Stem CellsRestore V(D)J-Recombinase and Rescue Lymphoid Deficiency

M. Pavel-Dinu, C. L. Gardner, Y. Nakauchi, T. Kawai, O. M. Delmonte, B. Palterer, M. Bosticardo, F. Pala, S. Viel, H. L. Malech, H. Y. Ghanim, N. N. Bode, G. L. Kurgan, C. A. Vakulskas, A. Sheikali, , M. H. Porteus

This study corrects the RAG2 gene in human hematopoietic stem cells to restore V(D)J recombination and lymphoid development in RAG2-SCID patients.

bioRxiv · Jul 12, 2022Immunology

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolism

W. Wang, A. DeVilbiss, M. Arreola, T. Mathews, Z. Zhao, M. Martin-Sandoval, G. Benegiamo, A. Awani, L. Goeminne, D. Dever, Y. Nakauchi, M. Pavel-Dinu, W. Al-Herz, L. Noratangelo, M. H. Porteus, , K. G. Weinacht

This study shows AK2 deficiency disrupts mitochondrial metabolism, causing purine metabolism disorder and myelopoiesis failure through AMP accumulation and NAD+ depletion.

bioRxiv · Jul 5, 2021 · PreprintCell Biology