Author

H. Lerche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Approach:statistical model· 1

Frequent Co-Authors

Y. Liu· 2 shared A. Jorgensen· 1 shared A. Marson· 1 shared B. P. Koeleman· 1 shared C. Campbell· 1 shared C. Depondt· 1 shared C. Leu· 1 shared D. Lewis-Smith· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

Y. Liu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

S. Quinn, N. Zhang, T. A. Fenton, M. Brusel, P. Muruganandam, Y. Peleg, M. Giladi, Y. Haitin, H. Lerche, H. Bassan, Y. Liu, R. Ben-Shalom, M. Rubinstein

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

bioRxiv · Dec 4, 2023 · PreprintPhysiology

Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities

C. Campbell, D. Lewis-Smith, C. Leu, H. Martins, S. Wolking, R. Krause, T. J. O'Brien, G. Sills, F. Zara, B. P. Koeleman, C. Depondt, A. Marson, H. Stefansson, K. Stefansson, J. Craig, , G. Cavalleri

This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.

medRxiv · Jul 4, 2023 · PreprintGenetic & Genomic Medicine

In vitro effects of S-Licarbazepine as a potential precision therapy on SCN8A variants causing neuropsychiatric disorders

E. Bayraktar, Y. Liu, U. B. S. Hedrich, Y. Sara, H. Lerche, T. V. Wuttke, S. Lauxmann

This paper investigates the effects of S-Licarbazepine on SCN8A variants in neuroblastoma cells, showing variant-specific modulation of NaV1.6 channel biophysical properties.

bioRxiv · Apr 24, 2021Pharmacology & Toxicology