Author

M. Giladi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 5 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:cell signaling & trafficking· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Y. Haitin· 7 shared P. Man· 3 shared P. Vankova· 3 shared E. Melvin· 2 shared M. Lisnyansky Bar-El· 2 shared A. Ben-Bassat· 1 shared A. Ferofontov· 1 shared A. Loewenstein· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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7 shared papersBiochemistry

Y. Haitin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

S. Quinn, N. Zhang, T. A. Fenton, M. Brusel, P. Muruganandam, Y. Peleg, M. Giladi, Y. Haitin, H. Lerche, H. Bassan, Y. Liu, R. Ben-Shalom, M. Rubinstein

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

bioRxiv · Dec 4, 2023 · PreprintPhysiology

Chloride intracellular channel (CLIC) proteins function as fusogens

B. Manori, A. Vaknin, P. Vankova, A. Nitzan, R. Zaidel-Bar, P. Man, M. Giladi, Y. Haitin

This study identifies CLIC5 as a fusogen, showing it induces membrane fusion and its activity is pH-dependent and requires a conserved hydrophobic interface.

bioRxiv · Aug 27, 2023 · PreprintBiochemistry

Structural basis for long-chain isoprenoids synthesis by cis-prenyltransferases

M. Giladi, M. Lisnyansky Bar-El, P. Vankova, A. Ferofontov, E. Melvin, D. Kavan, B. Redko, E. Haimov, R. Wiener, P. Man, Y. Haitin

This paper investigates the structural basis for long-chain isoprenoid synthesis by human cis-prenyltransferase, revealing a mechanism for directional product synthesis and membrane insertion.

bioRxiv · Oct 21, 2021Biochemistry

TTYH family members form tetrameric complexes within the cell membrane

E. Melvin, E. Shlush, M. Giladi, Y. Haitin

This study shows that mTTYH1 and mTTYH3 form tetramers at the plasma membrane, which dissociate into dimers upon detergent solubilization.

bioRxiv · Sep 5, 2021Biochemistry

Structure of the human heterotetrameric cis-prenyltransferase complex

M. Lisnyansky Bar-El, P. Vankova, P. Man, Y. Haitin, M. Giladi

The paper determines the structure of the human cis-prenyltransferase complex, revealing its heterotetrameric assembly and molecular mechanism of dolichol synthesis and disease-related mutations.

bioRxiv · Jun 2, 2020Biochemistry

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approach

M. Lisnyansky Barel, S. Y. Lee, A. Y. Ki, N. Kapelushnik, A. Loewenstein, K. Y. Chung, D. Schneidman-Duhovny, M. Giladi, H. Newman, Y. Haitin

The paper presents a structural model of full-length human DHDDS using computational and experimental methods, revealing a helix-loop-helix motif in the C-terminal domain and a DHDDS-NgBR heterodimer structure.

bioRxiv · Oct 7, 2019Biophysics

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge

A. Ben-Bassat, M. Giladi, Y. Haitin

The paper presents a 1.5 Å resolution structure of the hKCNH2 CNBHD, revealing a novel salt-bridge critical for channel function and structural stability.

bioRxiv · Oct 3, 2019Biophysics