Author

H. M. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Approach:benchmark study· 1

Frequent Co-Authors

M. Tokuyama· 4 shared S. Mehandru· 4 shared A. Livanos· 3 shared C. Argmann· 3 shared D. Jha· 3 shared J.-F. Colombel· 3 shared M. Suarez-Farinas· 3 shared A. D. Polydorides· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

M. Tokuyama

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

D. Jha, Z. Al-Taie, A. Krek, S. T. Eshghi, A. Fantou, T. Laurent, M. Tankelevich, X. Cao, H. Meringer, A. Livanos, M. Tokuyama, F. Cossarini, A. Bourreille, R. Josien, R. Hou, , S. Mehandru

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

bioRxiv · Jun 2, 2023 · PreprintImmunology

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

P. Canales-Herrerias, M. Uzzan, A. Seki, R. S. Czepielewski, B. Verstockt, A. Livanos, F. Raso, A. Dunn, D. Dai, A. Wang, Z. Al-taie, J. Martin, H. M. Ko, M. Tokuyama, M. Tankelevich, , S. Mehandru

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

bioRxiv · Jan 19, 2023Immunology

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

M. Suarez-Farinas, M. Tokuyama, G. Wei, R. Huang, A. Livanos, D. Jha, A. Levescot, H. Irizar, R. Kosoy, S. Cording, W. Wang, H. Irizar, R. Ungaro, A. Di Narzo, G. Martinez-Delgado, , S. Mehandru

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

bioRxiv · May 21, 2020Immunology

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

M. Uzzan, M. Tokuyama, A. K. Rosenstein, C. Tomescu, I. N. SahBandar, H. M. Ko, L. Leyre, A. Chokola, E. Kaplan-Lewis, G. Rodriguez, A. Seki, M. J. Corley, J. Aberg, A. La Porte, E.-y. Park, , S. Mehandru

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.

bioRxiv · Jun 14, 2018Immunology