S. Mehandru

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

The paper identifies a new subset of tonsillar memory B cells that serve as precursors for IgD-secreting plasma cells, contributing to steady-state IgD responses to common antigens.

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

This study identifies anti-integrin αvβ6 autoantibodies as a predictive biomarker for ulcerative colitis, showing they precede diagnosis by up to 10 years and correlate with adverse outcomes.

Defining Innate Immune Responses to the Human Gut Microbiota from Phylum to Strain

This study screens 277 gut bacterial strains to define innate immune responses, showing strain-specific and phylum-level variations in immune activation.

Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota

This study shows gut IgA enhances systemic IgG responses to pneumococcal vaccines by regulating antigen translocation and immune activation via the microbiota.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.